Diabetes & Metabolism Journal

Original Articles

Obesity and Metabolic Syndrome
Prediction of Gestational Diabetes Mellitus in Pregnant Korean Women Based on Abdominal Subcutaneous Fat Thickness as Measured by Ultrasonography: Sung Hee Yang, Changsoo Kim, Hyun Sook An, Hyun An, Jin Soo Lee; Diabetes Metab J. 2017;41(6):486-491. Published online September 22, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.6.486

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Background

This study was performed to verify the correlation between abdominal subcutaneous fat thickness (ASFT) measured by ultrasonography (US) during the first trimester of pregnancy and gestational diabetes mellitus (GDM) of the second trimester in Korean women and to establish a standard of ASFT for predicting GDM.

Methods

A total of 333 singleton pregnant women participated in this study. Their ASFT was measured by US during the 10⁺⁶ to 13⁺⁶ weeks of pregnancy; then a GDM confirmatory test (100 g oral glucose tolerance test) was conducted during the 24 to 28 week period of pregnancy. Based on the GDM tests, comparative analyses of the ages of the subjects, pre-pregnancy body mass index (BMI), and weight gain during pregnancy were conducted.

Results

The ages of the subjects and weight gains during pregnancy were not correlated to the GDM of the second trimester of pregnancy, but the pre-pregnancy BMIs (22±3.3 kg/m²) and the ASFT (1.9±0.5 cm) measurements between the control group and subjects during the first trimester of pregnancy were found to show significant differences (P<0.001). The cut-off value of the ASFT for predicting GDM was determined to be 2.4 cm (area under the curve=0.90, sensitivity 75.61%, specificity 91.78%, P<0.001). The odds ratio was 2.91 (95% confidence interval, 1.07 to 7.92; P=0.034), which was higher than the 2.4 cm ASFT.

Conclusion

It was determined that ASFT as measured by US during the first trimester of pregnancy can be used to predict the risk of developing GDM during the second trimester of pregnancy and for prognosis.

Citations

Citations to this article as recorded by

Abdominal subcutaneous fat thickness combined with a 50-g glucose challenge test at 24-28 weeks of pregnancy in predicting gestational diabetes mellitus
Süleyman Cemil Oğlak, Emine Zeynep Yılmaz, Mehmet Şükrü Budak
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The Value of Maternal Upper Abdominal Ad-ipose Thickness in Predicting GDM in Early Pregnancy
娜娜郭
Advances in Clinical Medicine.2023; 13(03): 4702. CrossRef
Evaluating the Adipose Tissue Depth as a Predictor Factor for Gestational Diabetes in Later Pregnancy—A Systematic Review
Bianca-Margareta Salmen, Valeria-Anca Pietrosel, Cristiana-Elena Durdu, Teodor Salmen, Cosmina Theodora Diaconu, Ioana-Cristina Bica, Claudia Gabriela Potcovaru, Florentina Gherghiceanu, Roxana-Adriana Stoica, Anca Pantea Stoian
Biomedicines.2023; 11(5): 1492. CrossRef
The Association Between Body Fat Index and Gestational Diabetes Mellitus: A Prospective Cohort Study
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Ultrasound evaluation of subcutaneous and visceral abdominal fat as a predictor of gestational diabetes mellitus: a systematic review
Fernanda Teixeira Benevides, Edward Araujo Júnior, Carla Soraya Costa Maia, Renan Magalhães Montenegro Junior, Francisco Herlânio Costa Carvalho
The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(11): 2216. CrossRef
The Early Sonographic Prediction of Gestational Diabetes in Women From India
Shivani Gupta, Arjun Gupta, C. P. Swarnakar, Monika Rathore, Ramesh Beniwal, Kiran Meena, Anita Simlot, Nidhi Gupta
Journal of Diagnostic Medical Sonography.2022; 38(1): 18. CrossRef
Can maternal abdominal fat thickness predict antenatal insulin therapy in patients with gestational diabetes mellitus?
Sedat Akgöl, Mehmet Şükrü Budak, Süleyman Cemil Oğlak, Fatma Ölmez, Mehmet Emin Dilek, Serhat Kartal
Journal of Obstetrics and Gynaecology Research.2022; 48(3): 634. CrossRef
Prediction of gestational diabetes mellitus by different obesity indices
Zhimin Song, Yan Cheng, Tingting Li, Yongfang Fan, Qingying Zhang, Haidong Cheng
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Association between maternal adiposity measures and adverse maternal outcomes of pregnancy: Systematic review and meta‐analysis
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Obesity Reviews.2022;[Epub] CrossRef
Association of body composition in early pregnancy with gestational diabetes mellitus: A meta-analysis
Fatemeh Alsadat Rahnemaei, Fatemeh Abdi, Reza Pakzad, Seyedeh Hajar Sharami, Fatemeh Mokhtari, Elham Kazemian, Rajakumar Anbazhagan
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Relationship between Maternal Central Obesity and the Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies
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Maternal Adipose Tissue Expansion, A Missing Link in the Prediction of Birth Weight Centile
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Francesco D’Ambrosi, Gabriele Rossi, Chiara M. Soldavini, Matteo Di Maso, Ilma F. Carbone, Giulia E. Cetera, Enrico Colosi, Enrico Ferrazzi
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Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
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Fetal pancreatic hyperechogenicity may be an early ultrasonographic sign of gestational diabetes mellitus
Hatice Akkaya, Barış Büke, Gülsüm Uysal
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The Body Composition in Early Pregnancy is Associated with the Risk of Development of Gestational Diabetes Mellitus Late During the Second Trimester

Yanping Liu, Jing Liu, Yinjie Gao, Dan Zheng, Wei Pan, Min Nie, Liangkun Ma
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 2367. CrossRef
New Diagnostic Criteria for Gestational Diabetes Mellitus and Pregnancy Outcomes in Korea
Kyu Yeon Hur
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Inter and intra-reliability of ultrasonography for the measurement of abdominal subcutaneous & visceral adipose tissue thickness at 12 weeks gestation
Alexandra Cremona, Kevin Hayes, Clodagh S. O’Gorman, Ciara Ní Laighin, Khadijah I. Ismail, Alan E. Donnelly, Jill Hamilton, Amanda Cotter
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Maternal abdominal subcutaneous fat thickness as a simple predictor for gestational diabetes mellitus
Mehmet Sukru Budak, Ilker Kahramanoglu, Salvatore Giovanni Vitale, Sedat Akgol, Mehmet Emin Dilek, Serhat Kartal, Salvatore Caruso, Bekir Kahveci, Mehmet Obut, Muhammed Hanifi Bademkiran, Antonio Cianci
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Hypertriglyceridemia and Waist Phenotype as Markers in the Prediction of Gestational Diabetes in Iraqi Women
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The importance of treating mild hyperglycemia in pregnant women with diabetes
Kyung-Soo Kim
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Anthropometric and ultrasound measures of maternal adiposity in the first trimester of pregnancy
Narelle Kennedy, Ann Quinton, Michael John Peek, Valeria Lanzarone, Ron Benzie, Ralph Nanan
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Simple Screening Using Ultrasonography for Prediction of Gestational Diabetes Mellitus
Seung Min Chung, Jun Sung Moon
Diabetes & Metabolism Journal.2017; 41(6): 438. CrossRef

Clinical Diabetes & Therapeutics
Determinants of Long-Term Durable Glycemic Control in New-Onset Type 2 Diabetes Mellitus: Kyoung Jin Kim, Ju Hee Choi, Kyeong Jin Kim, Jee Hyun An, Hee Young Kim, Sin Gon Kim, Nam Hoon Kim; Diabetes Metab J. 2017;41(4):284-295. Published online August 3, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.4.284

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Abstract PDF Supplementary Material PubReader

Background

Long-term durable glycemic control is a difficult goal in the management of type 2 diabetes mellitus (T2DM). We evaluated the factors associated with durable glycemic control in a real clinical setting.

Methods

We retrospectively reviewed the medical records of 194 new-onset, drug-naïve patients with T2DM who were diagnosed between January 2011 and March 2013, and were followed up for >2 years. Glycemic durability was defined as the maintenance of optimal glycemic control (glycosylated hemoglobin [HbA1c] <7.0%) for 2 years without substitution or adding other glucose-lowering agents. Clinical factors and glycemic markers associated with glycemic durability were compared between two groups: a durability group and a non-durability group.

Results

Patients in the durability group had a higher baseline body mass index (26.1 kg/m² vs. 24.9 kg/m²) and lower HbA1c (8.6% vs. 9.7%) than the non-durability group. The initial choice of glucose-lowering agents was similar in both groups, except for insulin and sulfonylureas, which were more frequently prescribed in the non-durability group. In multiple logistic regression analyses, higher levels of education, physical activity, and homeostasis model assessment of β-cell function (HOMA-β) were associated with glycemic durability. Notably, lower HbA1c (<7.0%) at baseline and first follow-up were significantly associated with glycemic durability (adjusted odds ratio [OR], 7.48; 95% confidence interval [CI], 2.51 to 22.3) (adjusted OR, 9.27; 95% CI, 1.62 to 53.1, respectively), after adjusting for confounding variables including the types of glucose-lowering agents.

Conclusion

Early achievement of HbA1c level within the glycemic target was a determinant of long-term glycemic durability in new-onset T2DM, as were higher levels of education, physical activity, and HOMA-β.

Citations

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Initial Combination Therapy in Type 2 Diabetes
Ji Yoon Kim, Nam Hoon Kim
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Greater Glycemic Burden Is Associated with Further Poorer Glycemic Control in Newly-Diagnosed Type 2 Diabetes Mellitus Patients
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Frontiers in Endocrinology.2022;[Epub] CrossRef
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Danpei Li, HuaJie Zou, Ping Yin, Wenjun Li, Junyu He, Shuyun Wang, Li Huang, Shiying Shao, Yong Chen, Yan Yang, Xuefeng Yu
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Linong Ji, Juliana C. N. Chan, Miao Yu, Kun Ho Yoon, Sin Gon Kim, Sung Hee Choi, Chien‐Ning Huang, Shih Te Tu, Chih‐Yuan Wang, Päivi Maria Paldánius, Wayne H. H. Sheu
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Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study
Kyoung Jin Kim, Jimi Choi, Jae Hyun Bae, Kyeong Jin Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim, Nam Hoon Kim
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Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study (Diabetes Metab J 2021;45:368-78)
Ja Young Jeon
Diabetes & Metabolism Journal.2021; 45(4): 613. CrossRef
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Factors Associated with Poor Hemoglobin A1c Control in Patients with Type 2 Diabetes
Salam Alqudah, Anan S. Jarab, Eman A. Alefishat, Fadia Mayyas, Maher Khdour, Sharrel Pinto
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Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey: Ja Young Jeon, Dae Jung Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Soo Lim, Sung Hee Choi, Chul Sik Kim, Jee Hyun An, Nan Hee Kim, Jong Chul Won, Jae Hyeon Kim, Bong-Yun Cha, Kee-Ho Song; Diabetes Metab J. 2014;38(3):197-203. Published online June 17, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.3.197

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Abstract PDF PubReader

Background

The Korea National Health and Nutrition Examination Survey (KNHANES) III (2005) reported that 22.9% of individuals with diabetes have a glycated hemoglobin (HbA1c) <6.5% and that 43.5% have an HbA1c <7%. We investigated the levels of glycemic control and the factors associated with glycemic control using data from the KNHANES V (2010 to 2012).

Methods

Subjects with diabetes diagnosed by a physician or those taking antidiabetic medications were classified as individuals with known diabetes. Of 1,498 subjects aged ≥30 years with diabetes, we excluded 157 individuals who were missing HbA1c data. A total of 1,341 subjects were included in the final analysis.

Results

The prevalence of known diabetes was 7.7% (n=1,498, estimated to be 2.32 million people). The proportions of well-controlled diabetes meeting a HbA1c goal of <6.5% and <7% were 27% and 45.6%, respectively. HbA1c increased as the duration of diabetes increased. HbA1c in subjects with a duration of diabetes ≤5 years was lower than in subjects with a duration >5 years. HbA1c in the group taking only oral hypoglycemic agents (OHAs) was significantly lower than that in the group administered only insulin or OHA and insulin in combination. In logistic regression analysis, a longer duration of diabetes, insulin use and the absence of chronic renal failure were associated with HbA1c levels >6.5%.

Conclusion

The level of adequate glycemic control was similar to but slightly improved compared with previous levels. The glycemic control of long-standing diabetes patients is more difficult even though they receive insulin treatment.

Citations

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Prevalence and Clinical Characteristics of Aspirin Resistance in the Patients with Type 2 Diabetes Mellitus.: Mi Yeon Kang, Young Min Cho, Hyun Kyung Kim, Jee Hyun An, Hwa Young Ahn, Ji Won Yoon, Hoon Sung Choi, Jie Seon Lee, Kyong Soo Park, Seong Yeon Kim, Hong Kyu Lee; Korean Diabetes J. 2008;32(1):53-59. Published online February 1, 2008; DOI: https://doi.org/10.4093/kdj.2008.32.1.53

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BACKGROUND
We examined the prevalence and clinical characteristics of aspirin resistance in the Korean patients with type 2 diabetes mellitus. METHODS: We studied 181 Korean patients with type 2 diabetes mellitus who were taking aspirin (100 mg/day for > or = 3 months) and no other antiplatelet agents. The VerifyNow System was used to determine aspirin responsiveness. Aspirin resistance was defined as an aspirin reaction unit (ARU) > or = 550. We measured the cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) to evaluate arteriosclerosis. The anthropometric parameters, electrocardiogram, blood pressure, fasting plasma glucose, lipid profiles, hemoglobin A1c, highly sensitive C-reactive protein (hsCRP), homocysteine, and microalbuminuria were measured in each patient. RESULTS: The prevalence of aspirin resistance in type 2 diabetic patients was 9.4% (17 of 181). Those who had aspirin resistance were older than those without aspirin resistance (64.6 +/- 10.6 vs. 59.8 +/- 8.1, P = 0.024). Aspirin resistance was not associated with fasting plasma glucose, total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, hemoglobin A1c, hsCRP, homocysteine, microalbuminuria, ABI, CAVI, and body mass index. CONCLUSION: Prevalence of aspirin resistance in the Korean patients with type 2 diabetes mellitus was 9.4%. Although aspirin resistance was associated with old age, we could not find any good clinical parameter to predict it. Therefore, aspirin resistance should be evaluated in diabetic patients taking aspirin for prevention of cardiovascular complications.

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Long Non-Coding RNA H19 Positively Associates With Aspirin Resistance in the Patients of Cerebral Ischemic Stroke
Jue Wang, Bin Cao, Yan Gao, Dong Han, Haiping Zhao, Yuhua Chen, Yumin Luo, Juan Feng, Yanxia Guo
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